Combined with four cases, this paper introduces professor Li Qizhong’s experience in treating epigastric pain with combined Sini Powder. Professor Li believes that epigastric pain is usually caused by the liver and the stomach. First of all, he pays attention to soothing liver and harmonizing stomach with combined Sini Powder. As appropriate, Sini Powder with Sijunzi Soup is strengthening spleen and invigorating qi,with Huangqi Jianzhong Soup is strengthening spleen and stomach,with Fuzi Lizhong Soup is warming middle energizer to stop diarrhea,with Banxia Xiexin Soup is mildly regulating cold and heat. Other small compounds such as Zuojin Pill,Jinglingzi Powder,Liangfu Pill and Erchen Soup are added or reduced based on syndrome differentiation.