Objective:To investigate the chemical constitutes from the stems of Sargentodoxa cuneata. MethodsCompounds were extracted by the method of system solvent,and isolated and purified by a combination of various chromatographic techniques,including silica gel column,ODS column,and preparative HPLC methods.Their structures were elucidated on the basis of their physiochemical property and NMR spectra.  Results:Ten compounds were obtained from 95% ethanol extract of the stems of Sargentodoxa cuneata and identified as staphylionoside D,4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranoside,vanillyl alcohol-4-O-β-D-glucopyranoside,3,4,5-trimethoxyphenyl-β-D-glucopyranoside,isotachioside,4-hydroxy-3,5-dimethoxy-phenol,dimethyl 2,3′-dimethoxyosoate,uridine,syringaldehyde and fomannoxin acid, respectively.  Conclusion:All compounds are isolated from the genus Sargentodoxa for the first time.