Objective:To provide theoretical basis for explaining the effectiveness of Renshenbaidu San in interfering with coronavirus disease 2019(COVID-19)by screening the effective components and targets of Renshenbaidu San via network pharmacology and exploring the internal relationship between Renshenbaidu San and COVID-19. MethodsTCMSP was used to find and screen the effective components and their corresponding targets of Renshenbaidu San. Cytoscape 3.7.2 was used to construct and analyze its network.DAVID and STRING databases were used to carry out enrichment analysis and PPI network construction. The effective components of the top 3 in degree value were molecular docking with angiotensin converting enzyme 2(ACE2).  Results:Through search and analysis,191 effective components of Renshenbaidu San were obtained,302 targets with repetitive information were eliminated,75 targets with intersection with COVID-19,439 GO analysis items,and 122 corresponding signal pathways in KEGG pathway enrichment analysis.Molecular docking results showed that quercetin,luteolin and kaempferol could all bind ACE2 effectively.  Conclusion:Renshenbaidu San has the advantages of multi-component and multi-target in interfering with COVID-19. The effective components and potential mechanism of Renshenbaidu San in interfering with COVID-19 are explored through network pharmacology method,which provide theoretical basis for further revealing its potential mechanism.