To review the clinical and basic research progress on Jixuecao(Centellae Herba) in the treatment of connective tissue disease-related pulmonary disease based on the understanding of connective tissue disease-related pulmonary disease in traditional Chinese medicine. The clinical research is carried out around clinical observation and mechanism research of traditional Chinese medicine compound containing Jixuecao (Centellae Herba ) in the treatment of connective tissue disease-related pulmonary disease. The basic research focuses on pharmacological effects of Jixuecao (Centellae Herba) and its extracts. It is suggested that the mechanism of Jixuecao (Centellae Herba) in the treatment of connective tissue disease-related pulmonary disease is closely related to its anti-inflammatory, anti-pulmonary fibrosis and anti-pulmonary hypertension effects.