To introduce Ni Juxiu’s clinical experience in the treatment of infantile febrile disease from both aspects of the lung and spleen. Taking the typical medical records of respiratory and digestive system diseases as an example, it is considered that in the treatment of infantile febrile disease, we should not only pay attention to the protection of yin and fluid, but also take into account the declination and exuberance of yang, and more importantly, observe the survival of stomach qi. If the cold Chinese medicine is used for a long time, it will consume stomach fluid, so it is appropriate to use some Chinese medicines with sweet-cold property and treat the disease from both aspects of the lung and spleen, and after the treatment was taken effect, it is necessary to stop using this kind of drugs.