Objective:To observe the effect of Tongsaimai tablets combined with conventional therapy on inflammatory factors and hemorheology in patients with diabetic foot. MethodsEighty patients with diabetic foot were randomly divided into treatment group and control group, with 40 cases in each group. The control group was given conventional therapy (to control blood sugar, improve microcirculation and fight infection, etc.), while the treatment group was given Tongsaimai tablets besides the conventional therapy as in the control group. The course of treatment in both groups was one month. The clinical efficacy was observed and the changes of related inflammatory indexes and hemorheological indexes were compared.  Results:①The total effective rate of the treatment group was 87.5% while that of the control group was 72.5%. The clinical efficacy of the treatment group was better than that of the control group (P＜0.05). ② The levels of serum WBC, CRP, IL-6 and TNF-α in the two groups all decreased when compared before and after treatment (P＜0.05). According to the comparison between two groups after treatment, the levels of WBC, CRP, IL-6 and TNF-α in the treatment group were lower than those in the control group (P＜0.05). ③There were significant differences in the levels of whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, hematocrit and erythrocyte electrophoresis speed in the treatment group before and after treatment (P＜0.05), but there was no significant difference in the levels of above indexes in the control group (P>0.05). After treatment, the levels of whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit in the treatment group were lower than those in the control group (P＜0.05), and the erythrocyte electrophoresis speed was higher than that in the control group (P＜0.05).  Conclusion:Compared with conventional therapy alone, the combined use of conventional therapy and Tongsaimai tablets can achieve more satisfactory effect on diabetic food treatment as Tongsaimai tablet can better inhibit inflammatory reaction and improve microcirculation.