To briefly summarize the clinical adverse reactions and reasonable application of Jinhuang preparation based on the theory of Gu-Wei-Hu-Chang(hoop protection field). Jinhuang preparation is one of the external preparations of TCM with good curative effect, which has the effect of clearing away heat to remove toxin and cooling blood to subside swelling. The Gu-Wei (hoop) method can mobilize and gather healthy qi to form a protective field to achieve the barrier function to prevent pathogenic factors from spreading and further accumulating. It is widely used as Gu-Wei medicine in the early stage of abscess and sores, which can achieve the function of limit sores and make the abscess subside.However, in the course of using, the adverse reactions of Jinhuang preparation caused by the difference of dosage forms and patients’ constitution should also be paid attention to.Therefore, when using Jinhuang preparation,it should be used flexibly according to the actual situation to avoid the occurrence of related adverse events.