Professor Su Xiao’s experience in the treatment of systemic lupus erythematosus(SLE)was summarized. Professor Su believed that the main pathogenesis of SLE was the congenital deficiency and the deficiency of liver and kidney. In the diagnosis and treatment, we should focus on the Chinese medicine and western medicine as a reference. Treatment should be specifically based on syndromes with consideration of the complementation of both medicines. When deficiency yin in liver and kidney occured, we should emphasize nourishing yin and clearing heat. When qi stagnation and blood stasis occured, resulting in accumulating heat, we should pay attention to clearing heat and invigorating blood circulation. When there were multiple symptoms, we should consider treating all of them at the same time. Spleen and stomach were priorities of health, so we should strengthen spleen and promote stomach. We should reinforce health education to prevent disease before it occured and to prevent deterioration.