Objective:To observe the clinical efficacy of alcoholic moxibustion in the treatment of children with mesenteric lymphadenitis(cold type of middle energizer). MethodsEighty-eight cases of mesenteric lymphadenitis in children with cold type of middle energizer were randomly divided into treatment group and control group, 44 cases in each group. The control group was given conventional Western medicine treatment only, and the treatment group was given alcoholic moxibustion combined with conventional Western medicine treatment. After 5 days of treatment, the indexes such as the clinical efficacy, total symptom score, length and transverse diameter of intestinal lymph nodes, duration of abdominal pain, recurrence rate and safety were observed.  Results:① The total effective rate of the treatment group and the control group was 95.4% and 88.6% respectively, and there was significant difference between the two groups (P<0.05). ② There were statistically significant differences in the total score of TCM syndrome and the long diameter and transverse diameter of mesenteric lymph nodes within groups before and after treatment in two groups(P<0.05). After treatment, there were significant differences in the total score of TCM syndrome and the long diameter and transverse diameter of mesenteric lymph nodes between two groups (P<0.05). ③ the disappearance time of abdominal pain in the treatment group (23 cases) was significantly shorter than that in the control group (14 cases). The difference was statistically significant (P<0.05). ④ the recurrence rates in the treatment group and the control group were 8.7% and 57.1%, respectively. There was significant difference in recurrence between the two groups (P<0.05). ⑤ during the trial, no abnormal urine routine, abnormal liver and kidney function and abnormal ECG occurred in all the children in the two groups.  Conclusion:The clinical effect of alcoholic moxibustion in the treatment of mesenteric lymphadenitis in children with cold type of middle energizer is obvious. It can shorten the duration of abdominal pain, improve the total score of symptoms, reduce the value of the long and transverse diameter of mesenteric lymph nodes, and reduce the recurrence rate. It is simple in operation, no adverse reactions, worthy of further clinical promotion.