The pathological mechanism and the treatment strategy of integrated traditional Chinese and western medicine of coronavirus disease 2019 (COVID-19) complicated with cardiovascular diseases was discussed based on psychocardiology. It is believed that anxiety and depression can aggravate the condition of COVID-19 patients with cardiovascular diseases, and its mechanism may be related to the activation of renin-angiotensin system.Clinically, physical therapies such as counseling, Chinese medical exercises, five-element music and other intervention measures such as western medicine can be adopted for the treatment. Traditional Chinese medicine can also play its role by differentiating syndromes like liver qi stagnation, heart-spleen deficiency,stasis and obstruction of heart vessel, and phlegm-fire disturbing the heart and then treating them accordingly.