Objective:To observe the clinical study of modified Shaoyao Gancao decoction combined with tandospirone citrate in treatment of post-stroke cerebellar ataxia. MethodsOne hundred and sixteen patients with post-stroke cerebellar ataxia were randomly divided into treatment group and control group,58 patients in each group,the control group was treated with basic treatment plus tandorone citrate,and the treatment group was treated with modified Shaoyao Gancao decoction on the basis of the control group. The course of treatment in both groups was 4 weeks. The clinical efficacy,Berg Balance Scale(BBS)scores,Modified Barthel Index(MBI)scores, Transcranial Doppler(TCD) ultrasonography of the posterior inferior cerebellar artery,Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and adverse reactions of the two groups were observed.  Results:①The total effective rate of treatment group and control group was 91.38% and 72.41%,and the clinical effect of the treatment group after treatment was better than that of the control group(P<0.05)；②BBS scores and MBI scores of the two groups after treatment were significantly higher than those before treatment(P<0.05),and the treatment group were better than those of the control group(P<0.05)；③TCD in the two groups showed that the peak systolic velocity(Vs),end diastolic velocity(Vd)and mean velocity(Vm)were significantly higher than those before treatment(P<0.05),the levels of Pulsatility Index(PI)and Resistive Index(RI)were significantly lower than those before treatment(P<0.05),and the treatment group were better than those of the control group(P<0.05)； ④The levels of HAMA and HAMD in the two groups after treatment were significantly lower than those before treatment(P<0.05), and the treatment group were better than those of the control group(P<0.05)；⑤Incidence of adverse reactions in the treatment group were lower than those in the control group(P<0.05).  Conclusion:Modified Shaoyao Gancao decoction combined with tandospirone citrate has a significant effect on post-stroke cerebellar ataxia, which can improve the balance ability and activity of daily life,obviously improve the TCD level of the posterior inferior cerebellar artery and anxiety and depression,it is safety and worthy of clinical application.