Objective: To observe the effects of Gantang Yifang (GTYF) and its disassembled prescriptions—Fuzheng Huayu(FZHY)recipe and Shipi (spleen-firming) recipe on liver fibrosis and abnormal glucose metabolism in cirrhotic rats induced by CCl,4,. Methods A total of 98 SPF Wistar rats were randomly divided into 6 groups including normal group,model group,GTYF group,Shipi group,FZHY group and metformin group. All rats except the rats in the normal group were modelled by subcutaneous injection of 40%CCl,4, olive oil solution combined with high-fat diet. From the fifth week of modeling, the rats in medication groups were given intragastric administration according to body mass once a day for 8 weeks. At 12 weeks, the glucose tolerance of rats was measured by OGTT test; the levels of blood glucose AUC and serum insulin were compared; and the insulin resistance index (HOMA-IR) was calculated. The body mass, liver mass and spleen mass of the rats were recorded, and the liver-to-body ratio and spleen-to-body ratio were calculated. Serum and tissue samples were collected to detect the levels of serum ALT, AST, Alb and TBiL. Liver steatosis was observed by HE staining, collagen deposition by Sirius red staining, and the content of hydroxyproline (Hyp) in liver tissue determined by colorimetry.  Results:Compared with the model group, GTYF and FZHY recipe could significantly improve the abnormal glucose tolerance, reduce the blood glucose AUC (P,<,0.05) and HOMA-IR (P,<,0.05), and the fasting insulin concentration in the Shipi recipe group was significantly lower than that in the model group (P,<,0.05). The results of serum biochemical test showed that GTYF and Shipi recipe could reduce the level of ALT (P,<,0.05) and Shipi recipe could also reduce the level of AST (P,<,0.05). The results of HE staining showed that GTYF could significantly reduce the steatosis of hepatocytes, and Sirius red staining showed that GTYF and FZHY recipe could significantly reduce the collagen area of the liver and the content of Hyp in liver tissue (P,<,0.05,P,<,0.01).  Conclusion:GTYF and its disassembled prescriptions—FZHY recipe and Shipi recipe can relieve hepatogenic diabetes induced by CCl,4, combined with high-fat diet by reducing hepatic steatosis and fibrosis, regulating and improving abnormal glucose tolerance and insulin resistance.