Based on two cured cases of lung pestilence with high fever and lung pestilence with sudden onset of severe cough, TCM clinical thinking pattern, syndrome differentiation and medication methods for the treatment of corona virus disease 2019 (COVID-19) were introduced. It is believed that COVID-19 can be treated according to the treatment of lung pestilence, and severe patients should be treated with traditional Chinese medicine as early as possible. Syndromes should be differentiated based on the individual, climatic and geographic factors, as well as the results of modern medicine examinations.