Objective:To explore Tian JianHui’s TCM medication rules in treating gynecological cancers with the method of data mining. MethodsThe medical records of patients with cervical cancer (CC), ovarian cancer (OVC) and endometrial cancer (EC) treated by Tian Jianhui were collected and sorted out. Through frequency analysis, association rules and entropy clustering analysis, the relevant core drug combinations in the prescription and the drug compatibility rules hidden in the prescription were discovered.  Results:①In this study 307 cases were included, including 157 cases of CC, 100 cases of OVC and 50 cases of EC. A total of 1,133 prescriptions were included, involving 325 kinds of herbs. ②There were 19 kinds of herbs used more than 350 times, which mainly enter into the liver, spleen and kidney meridians (accounting for 52.2% of all drugs); In the classification of herb efficacy, heat-clearing herbs accounted for 29.6%, deficiency-tonifying herbs accounted for 21.5%, diuresis-promoting and dampness-permeating herbs accounted for 9.7%, digestion-promoting herbs accounted for 6.8%, and blood-activating and stasis-resolving herbs accounted for 5.0%. ③Based on association rule analysis, the core prescription composed of 19 herbs for tonifying liver and kidney, detoxifying, anticancer and harmonizing heart and spleen was found, including Shu Dihuang, Shanzhuyu, Mudanpi, Shanyao, Fulin, Zexie, Sheng Huangqi, Tusizi, Shuyangquan, Tufulin, Longkui, Ezhu, Huangbai, Baijiangcao, Jineijin, Daoya, Suanzaoren, Dazao, Zhi Gancao. ④Based on entropy clustering analysis, 40 core combinations containing 3 to 4 herbs were obtained. On this basis, unsupervised entropy hierarchical clustering analysis was carried out, and 8 new prescriptions were obtained.  Conclusion:Tian Jianhui’s treatment of gynecological cancers focuses on the treatment of liver and kidney, and the core prescriptions are mainly for tonifying liver and kidney, detoxifying and anti-cancer, harmonizing spleen and stomach, and nourishing heart and tranquilizing mind.