Objective:To observe the clinical effect of acupoint application of cinnamon powder combined with conventional western medicine on gastrointestinal dysfunction in patients with spleen yang deficiency sepsis. MethodsNinety patients with gastrointestinal dysfunction of spleen yang deficiency sepsis were randomly divided into treatment group and control group, 45 cases in each group. The control group was given conventional western medicine treatment, and the treatment group was given cinnamon powder acupoint application besides the treatment measures of the control group. The two groups were treated for 7 days continuously. The changes of gastrointestinal dysfunction score, bowel sound score, abdominal circumference, intra-abdominal pressure, mean gastric retention volume, acute gastrointestinal injury (AGI) grade, acute physiology function and APACHE II score, TCM syndrome score, laboratory correlation index [WBC and PCT] were observed and compared. The incidence of multiple organ dysfunction syndrome (MODS) and 28-day mortality were followed up.  Results:①During the experiment, 1 case dropped out in the control group, 2 cases dropped out in the treatment group and 87 cases in total completed the experiment, including 44 cases in the control group and 43 cases in the treatment group. ②After treatment, the gastrointestinal dysfunction score, bowel sound score, abdominal circumference, intra-abdominal pressure and mean gastric retention volume of both groups decreased compared with those before treatment (P<0.05). After treatment, the gastrointestinal dysfunction score, bowel sound score, abdominal circumference, intra-abdominal pressure and mean gastric retention volume in the treatment group were lower than those in the control group (P<0.05). ③After treatment, there was improvement of the AGI grade in both groups (P<0.05); after treatment, the AGI grade of the treatment group was better than that of the control group (P<0.05). ④After treatment, the scores of Apache Ⅱ and TCM syndrome in the two groups both decreased (P<0.05); the scores of Apache Ⅱ and TCM syndrome in the treatment group were even lower than those in the control group (P<0.05). ⑤After treatment, the serum WBC and PCT levels of the two groups were both lower than before (P<0.05); after treatment, the serum WBC and PCT levels of the treatment group were lower than those of the control group (P<0.05). ⑥The incidence of MODS was 7.0% in the treatment group and 22.7% in the control group. The incidence of MODS in the treatment group was lower than that in the control group (P<0.05); The 28-day mortality in the treatment group and the control group were 18.6% and 25.0%, respectively, and the difference had no statistical significance (P>0.05).  Conclusion:Compared with conventional western medicine therapy, cinnamon powder acupoint application combined with conventional western medicine therapy can improve the gastrointestinal function, alleviate the disease condition, control the inflammatory reaction and reduce the incidence of MODS for patients with spleen yang deficiency type sepsis.