Combined application of ascending and descending natured Chinese medicine is one of the basic formula compatibility methods, i.e., opposite and complementary compatibility. According to the basic principle of the ascending and descending movement of qi, indications, and/or the requirements for formula compatibility, herbs with different characteristics of floating-ascending and descending-sinking are applied together to restore the normal ascending and descending of qi movement inside the human body and cure diseases. Combined application of both ascending and descending natured Chinese medicine is widely used in the clinic, not only for diseases with both ascending and descending disorders, but also for diseases with single ascending or descending disorders. More importantly, it is to remove the pathogenic heat by regulating the ascending and descending of qi rather than simply regulating the ascending and descending of qi.