Objective:To observe the clinical effect of fire acupuncture on common warts. MethodsRandomly divide 160 cases of common wart patientsA total of 160 cases of common wart patients were randomly divded into the treatment group and the control group, with 80 cases in each group. The control group was treated by local injection of myocellular cellspoly-myocyte in wart body, while the treatment group was treated by fire acupuncture. The treatment course was 28 days, and the clinical efficacy was observed. The changes of VAS pain score during treatment and the self-designed comprehensive grading score for common warts were compared, and the safety was also evaluated.  Results:①In the process of the experiment, 3 cases in the fire acupuncturetreatment group and 6 cases in the poly myocytecontrol group dropped out, and 151 cases were collected including 77 cases in the fire acupuncturetreatment group and 74 cases in the poly myocytecontrol group.②The total effective rate of the fire acupuncturetreatment group was 97.4%, and that of Poly I-Cthe control group was 73.0%. Compared with the two groups, the fire acupuncturetreatment group showed better clinical effects than the Poly I-Ccontrol group (P<0.05). ③Compared before the second treatment, before the third treatment and before the first treatment respectively, both groups had no significant difference in the self-designed grading score for common warts (P>0.05). Compared before the fourth treatment and before the first treatment, both groups showed significant differences in the self-designed grading score for common warts (P<0.05). Compared before the second treatment and before the third treatment, both groups showed no significant difference in the self-designed grading score for common warts (P>0.05). Comparison between groups before the fourth treatment showed that the self-designed grading score for common warts in the fire acupuncturetreatment group was lower than that in the Poly I-Ccontrol group (P<0.05).④There was no statistically significant difference in VAS pain score between the groups at the first treatment (P>0.05). The VAS pain score in the fire acupuncturetreatment group was lower than that in the myocellularcontrol group at the second, third and fourth treatment respectively (P<0.05). ⑤No obvious adverse reactions were observed in either group during the experiment.  Conclusion:The curative effect of fire acupuncture on common warts is satisfactory. Compared with Poly I-C injection therapy, it can better improve the clinical symptoms of patients with reduced pain and good safety, which is worthy of further clinical promotion and application.