Objective:To observe the combined effect of Jianpi Wenshen Ruanjian Jiedu formula, Kang’ai injection and low-dose chemotherapy on tumor focus, immune function and progression free survival (PFS) in elderly patients with advanced non-small cell lung cancer (NSCLC) of spleen kidney deficiency type. MethodsEighty elderly patients with advanced NSCLC of spleen kidney deficiency type were randomly divided into treatment group and control group, 40 cases in each group. The control group was given conventional dose chemotherapy, the treatment group was given Jianpi Wenshen Ruanjian Jiedu formula, Kangai injection combined with low-dose chemotherapy. After two cycles of chemotherapy, the tumor foci and immune function of the two groups were observed, and the PFS of patients were followed up.  Results:①During the experiment, 2 cases in the control group dropped out and 78 cases completed the experiment, including 40 cases in the treatment group and 38 cases in the control group. ②After the second chemotherapy, there was no statistical difference in the composition of tumor focus evaluation between the two groups (P,>,0.05). ③Both groups showed no significant difference in the serum levels of NK, CD3 ,+, CD4 ,+, CD8 ,+,after one cycle of chemotherapy compared with those before chemotherapy (P,>,0.05); the level of CD8 ,+, in the treatment group increased (P,<,0.05) while the level of NK, CD3,+, CD4 ,+, in the control group decreased (P,<,0.05) after two cycles of chemotherapy. After one cycle of chemotherapy, the levels of CD3 ,+, and CD4 ,+, in the treatment group were higher than those in the control group (P,<,0.05); after two cycles of chemotherapy, the levels of NK, CD3,+, and CD4,+, in the treatment group were higher than those in the control group (P,<,0.05). ④ The median PFS of the two groups was 4.5 months and the difference was not statistically significant(P,>,0.05).  Conclusion:Combined use of Jianpi Wenshen Ruanjian Jiedu formula, Kang’ai injection and low-dose chemotherapy can effectively control the changes of tumor foci in the elderly patients with lung and kidney deficiency type of NSCLC, stabilize the levels of serum NK, CD3,+, and CD4 ,+, and protect the immune function of the patients.