Objective:To observe the clinical effect of Chuanxiong Hualiu mixture on uterine myoma of qi stagnation and blood stasis pattern. MethodsA total of 80 patients with uterine myoma of qi stagnation and blood stasis pattern were randomly divided into two groups, 40 in each group. The research group (n=40) was administered Chuanxiong Hualiu mixture, and the control group (n=40) was given Guizhi Fuling capsules. The treatment course was three months. The clinical effects were observed and the changes of TCM syndrome score, uterine myoma volume, estradiol (E,2,), progesterone (P) were compared between the two groups.  Results:①The total effective rates of the treatment group and the control group were 85.0% and 62.5% respectively, and the clinical effect of the treatment group was significantly better than that of the control group (P,<,0.05). ②TCM syndrome score of the two groups both decreased after treatment, and the difference was statistically significant (P,<,0.05). The difference of TCM scores before and after treatment in the treatment group was significantly higher than that in the control group (P,<,0.05). ③The volume of uterine myoma in the two groups decreased after treatment, and the difference of uterine myoma volume in the treatment group compared before and after treatment was statistically significant (P,<,0.05), while the difference in the control group was not statistically significant (P,>,0.05). The difference of uterine myoma volume change between the groups before and after treatment was statistically significant (P,<,0.05). ④There were no significant differences in the levels of estradiol (E2) and progesterone (P) in the two groups (P,>,0.05) or between the two groups before and after treatment (P,>,0.05).  Conclusion:Compared with Guizhi Fuling capsules, Chuanxiong Hualiu mixture is more effective in reducing the volume of uterine myoma and improving clinical symptoms.