Objective:To investigate the effects of Jianpi Qinghua recipe on clinical indicators and arachidonic acid metabolism in patients suffering from metabolic syndrome (MetS) with impaired glucose regulation (IGR). MethodsSixty MetS patients with IGR were randomly assigned into control group and treatment group, 30 patients in each group. The control group received only lifestyle intervention and the treatment group were given oral treatment with Jianpi Qinghua recipe in addition to lifestyle intervention. The treatment course was 6 months in both groups. Changes were observed in waist circumference (WC), body mass index (BMI), glycosylated hemoglobin (HbA1c), blood lipid (TC, TG and LDL), carotid artery intima-media thickness (IMT) and arachidonic acid metabolites.  Results:①After treatment, the levels of WC, BMI, HbAlc and TG decreased in the treatment group (P<0.05), whereas there were no significant changes of indicators in the control group (P>0.05). The levels of WC and HbAlc decreased significantly in the treatment group compared to those in the control group (P<0.05). ②After treatment, IMT decreased in the treatment group (P<0.05), whereas there were no significant changes in the control group (P>0.05). The difference in IMT between the groups had no statistical significance (P>0.05). ③After treatment,the levels of 11-dehydroTXB2,11-dehydroTXB2/6-ketoPGF1a and 12-HETE decreased (P<0.05), whereas there were no significant changes in the control group (P>0.05). After treatment, 11-dehydroTXB2,11-dehydroTXB2/6-ketoPGF1a, 12-HETE, 9-HODE and 13-HODE decreased significantly in the treatment group compared to those in the control group (P<0.05).  Conclusion:Jianpi Qinghua recipe reduces body weight, improves blood sugar metabolism and delays the development of atherosclerosis. Its effect may be related to the regulation of different metabolic pathways of arachidonic acid in patients suffering from metabolic syndrome with impaired glucose regulation.