Objective:To investigate the clinical effect of dearterialization rectopexy and closed hemorrhoidectomy in the treatment of severe mixed hemorrhoids. MethodsRandomly divide 160 patients with severe mixed hemorrhoids into treatment group and control group with 80 cases in each group. PPH with closed external hemorrhoidectomy were performed in the control group while dearterialization rectopexy and closed hemorrhoidectomy were used in the treatment group. The operative time, intraoperative blood loss, postoperative complications (pain, urinary retention, bleeding), continence score, length of stay, wound healing time and treatment cost were observed and compared in two groups.  Results:①A total of 152 patients completed the experiment, including 74 cases in the treatment group and 78 cases in the control group. ②=2\*GB3The amount of intraoperative bleeding and hospitalization cost in the treatment group were less than those in the control group and the difference was statistically significant (P<0.05). ③=3\*GB3At the time of wound healing and 6 months after operation, the continence score of the two groups both decreased compared to that of the two groups before operation (P<0.05); but there was no significant difference between the two groups at each observation time point (P>0.05). ④=4\*GB3 There was no significant difference in operation time, postoperative complications and treatment, hospitalization time and wound healing time between the two groups (P>0.05).  Conclusion:It is safe, effective and economical to treat severe mixed hemorrhoids by dearterialization rectopexy and closed hemorrhoidectomy, and the operation is simple and convenient, which is worthy of clinical application.