Objective:To observe the clinical effect of integrated Chinese and western medicine rehabilitation program on post-stroke depression (PSD) of liver qi stagnation pattern. MethodsA total of 62 patients with liver qi stagnation pattern PSD were randomly divided into the treatment group and the control group with 31 cases in each group. The control group was treated with routine rehabilitation training of western medicine, and the treatment group was given the routine rehabilitation training of western medicine combined with the rehabilitation therapy of Chinese medicine (including self-designed Liqi Jieyu (qi-regulating and depression-relieving) formula, acupuncture and acupoint massage). The course of treatment was one month in both groups. The clinical effect was observed and the changes of HAMD, NIHSS and ADL scores were compared.  Results:①The total effective rate of the treatment group and the control group was 93.5% and 74.2% respectively, and the clinical effect of the treatment group was significantly better than that of the control group (P<0.05). ②Compared before and after treatment, HAMD scores and NIHSS scores of both groups were significantly lower (P<0.05), and ADL score were significantly higher (P<0.05); after treatment, HAMD scores and NIHSS score of the treatment group were significantly lower than those of the control group (P<0.05), and ADL score of the treatment group was significantly higher than that of the control group (P<0.05).  Conclusion:The integrated Chinese and western medicine rehabilitation program for the treatment of liver qi stagnation pattern PSD can effectively improve the depression state of patients, promote the recovery of neurological function and improve the quality of life.