Objective:To explore the medication rule of TCM master Liu Zuyi’s prescriptions for treating recovery phase of cerebral infarction and summarize his academic thoughts. MethodsProfessor Liu Zuyi’s prescriptions for treating recovery phase of cerebral infarction were collected to build a database based on Traditional Chinese Medicine Inheritance Support System(TCMISS). Then TCMISS was used for data mining and the medication rule of prescription was analyzed.  Results:①This study totally included 147 prescriptions involving 179 medical herbs with a cumulative frequency of 2 164. ②There were 22 kinds of medical herbs with frequency of use more than 20 times. The top 10 were Huangqi(Radix Astragali), Danshen (Radix Salviae Miltiorrhizae), Shanzha (Fructus Crataegi), Gegen (Radix Puerariae), Gouqizi (Fructus Lycii), Dilong(Lumbricus), Zhiheshouwu (Radix Polygoni Multiflori Preparata), Chuanxiong (Rhizoma Chuanxiong), Shichangpu (Rhizoma Acori Tatarinowii) and Yinyanghuo (Herba Epimedii). ③The dosage of Huangqi(Radix Astragali) could be seen from 15 g to 120 g, the most commonly used dosage is 30 g, and the range of commonly used dosage is mainly 30 g to 60 g.④=4\*GB3The top herbs in the classification of herb efficacy were the herbs with the functions of tonifying deficiency, activating blood circulation and removing blood stasis and the herbs of calming the liver and soothing wind, etc; ⑤The top 5 herb groups with high frequency of use were “Danshen (Radix Salviae Miltiorrhizae)-Huangqi(Radix Astragali)”, “Huangqi(Radix Astragali)-Shanzha (Fructus Crataegi)”, “Gegen (Radix Puerariae)-Huangqi(Radix Astragali)”, “Gegen (Radix Puerariae)-Danshen (Radix Salviae Miltiorrhizae)” and “Danshen (Radix Salviae Miltiorrhizae)-Shanzha (Fructus Crataegi)”. The herb groups with high correlation degree were Dilong(Lumbricus)-Huangqi(Radix Astragali), Gegen (Radix Puerariae)-Dilong(Lumbricus)-Huangqi(Radix Astragali), Danshen (Radix Salviae Miltiorrhizae)-Dilong(Lumbricus)-Huangqi(Radix Astragali),etc. ⑥=6\*GB3 Twelve core prescriptions were extracted by clustering analysis algorithm, and 6 potential new ones were evolved, such as a prescription including following herbs: Baishaoyao (Radix Paeoniae Alba),Weilingxian (Radix Clematidis), Guizhi (Ramulus Cinnamomi), Jixueteng (Caulis Spatholobi), Baijiezi (Semen Sinapis Albae)”and a prescripton including“Quanxie (Scorpio), Juhua (Flos Dendranthemae), Wugong (Scolopendra), Cijili(Fructus Tribuli).  Conclusion:The purpose of medication of TCM master Liu Zuyi in treating recovery phase of cerebral infarction is mainly nourishing qi and warming yang, replenishing essence and nourishing the kidney, activate blood circulation and dredge collaterals, calming internal wind and resolving phlegm, and the modified Qixian Tongluo prescription is used with heavy dosage of Huangqi(Radix Astragali) in it, which reflects Liu Zuyi’s academic thoughts of “Qi and yang dominating the life activities” and “mutual promotion between yin and yang in brain marrow”.