This paper introduces the clinical experience of Professor Xuan Guowei in the treatment of atopic dermatitis in children by sour-astringe method. It is considered that both surface deficiency and surface dryness are the basic pathogenesis characteristics of the disease. Sour-astringe method can regulate lung qi, converge heart spirit and liver qi. In the treatment of the disease, both the dispersing and astringe herbs are used. The herbs such as Wumei (Fructus Mume),Wuweizi (Fructus Schisandrae) and Baishaoyao (Radix Paeoniae Alba) are the most commonly used sour-astringe herbs, which can regulate the function of the lung, heart and liver, and achieve the effect of astringing yin without pathogenic factors left, dispelling pathogenic factors without healthy qi consumed through the cooperation with dispersing pungent herbs such as Zisuye (Folium Perillae),Fangfeng(Radix Ledebouriellae) and Chantui (Periostracum Cicadae). And one proven case is presented.