TAO Yanyan, CHEN Gaofeng, LIU Chenghai. Evaluation of animal models of acute liver injury and its application in pharmacology of traditional Chinese medicine[J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(11):11-19.
TAO Yanyan, CHEN Gaofeng, LIU Chenghai. Evaluation of animal models of acute liver injury and its application in pharmacology of traditional Chinese medicine[J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(11):11-19. DOI: 10.16305/j.1007-1334.2019.11.003.
Drug screening and pathological mechanism of acute liver injury depend largely on the establishment and application of experimental animal models. In this paper,five common animal models of acute liver injury,including CCl,4,ANIT,DDC,D-GalN/LPS and APAP,were selected and discussed in detail from the aspects of model preparation,biochemical characteristics,pathological mechanism,advantages/disadvantages,application of traditional Chinese medicine pharmacological research,etc.,which is of great significance for the prevention and treatment of acute liver injury.
关键词
急性肝损伤动物模型中药药理研究策略
Keywords
acute liver injuryanimal modelstraditional Chinese medicine pharmacologyresearch strategies