This paper introduces the experience of Professor Yu Jiangyi in the treatment of diabetic kidney disease(DKD) from the grease. Professor Yu considers that grease is compatible with adipose tissue and it is one of the manifestations of the spleen governing transportation and transformation. Since the disorder of grease in distribution and digestion is a triggering factor for DN, the method of treatment should adhere to the principle of invigorating spleen and eliminating dampness. He comes up with the Qikui granule, which consists of Zhihuangqi(Radix Astragali Preparata), Zhiheshouwu (Radix Polygoni multiflori Preparata) and Huangshukuihua(Flos Abelmoschi Manihot),being widely used in the clinical treatment of DN.