SUN Jie, CHENG Lihong, MIN Youjiang. Role of 11β-hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention[J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(9):90-94.
SUN Jie, CHENG Lihong, MIN Youjiang. Role of 11β-hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention[J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(9):90-94. DOI: 10.16305/j.1007-1334.2019.09.023.
This paper reviews the role and research of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1) in metabolic syndrome. 11β-HSD1 mediates insulin resistance in adipocytes via c-Jun N-terminal kinase (JNK) activation; hexose-6-phosphate dehydrogenase activates 11β-HSD1,causing insulin resistance; 11β-HSD1 on hippocampus (amygdala) -the HPA axis has a two-way adjustment. It has been found that some of Chinese medicine monomers and compounds can treat metabolic syndrome by regulating the level of 11β-HSD1.
关键词
代谢综合征11β-羟类固醇脱氢酶Ⅰ型11β-羟类固醇脱氢酶Ⅰ型抑制剂中药综述
Keywords
metabolic syndrome11β-hydroxysteroid dehydrogenase I11 β-hydroxysteroid dehydrogenase type I inhibitorChinese herbsreview