Objective:To observe the clinical efficacy of Qi’s Yangluan Decoction in treating patients with diminished ovarian reserve (DOR) in the course of in vitro fertilization and embryo transfer (IVF-ET). MethodsOne hundred and twenty patients with DOR who were prepared for IVF-ET were included and divided into the observation group and the control group by random number table, 60 cases in each group. After enrollment, the patients in the observation group were orally treated with Qi’s Yangluan Decoction, and the patients in the control group were orally treated with dehydroepiandrosterone (DHEA), with a course of three months. After treatment of 3 months, the patients in both groups entered the IVF-ET cycle. The levels of basal follicle stimulating hormone (bFSH), bFSH/luteinizing hormone (LH) and anti-mullerian hormone (AMH) and the antral follicle count (AFC) were compared between the two groups before and after treatment. During the IVF-ET cycle, the dosage of gonadotropin (Gn) and its use days, the numbers of the obtained ovum and the mature ovum, the total number of embryos, the number of high-quality embryos, the rates of mature ovum and the high-quality embryos, the cancellation rate of the cycle and the rate of clinical pregnancy were compared between the two groups.  Results:After treatment, the levels of bFSH and bFSH/LH in the two groups were decreased compared with before treatment (P<0.05), the level of AMH and the AFC were increased compared with before treatment (P<0.05), and the level of bFSH in the observation group was lower than that in the control group (P<0.05). In the cycle of IVF-ET, the dosage of Gn in the observation group was significantly less than that in the control group (P<0.05), the numbers of the obtained ovums and the mature ovums, the total number of embryos and the number of high-quality embryos in the observation group were more than those in the control group (P<0.05), and the rate of mature ovum in the observation group were was obviously higher than that in the control group (P<0.05).  Conclusion:Qi’s Yangluan Decoction can significantly improve the ovarian reserve function in patients with DOR, effectively enhance the ovarian responsiveness in the cycle of IVF-ET, and improve the outcome of assisted reproduction.