加味桃红四物汤灌胃治疗视网膜静脉阻塞大鼠的实验研究

吕小利; 邹红; 黎蕾; 缪晚虹

doi:10.16305/j.1007-1334.2019.08.020

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加味桃红四物汤灌胃治疗视网膜静脉阻塞大鼠的实验研究

实验研究 | 更新时间：2022-08-31

- 加味桃红四物汤灌胃治疗视网膜静脉阻塞大鼠的实验研究
- Experimental study on Supplemented Taohong Siwu Decoction for gavage administration in treatment of retinal vein occlusion in rats 
- 上海中医药杂志 2019年53卷第8期页码：81-88
- 作者机构：
  
  1. 上海中医药大学附属曙光医院眼科,上海,200021
  2. 复旦大学附属眼耳鼻喉科医院眼科,上海,200031
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上项目(81874384);上海市科委资助项目(17401970800);上海市中医药事业发展三年行动计划项目(上海市高级中西医结合人才培养项目)
- DOI：10.16305/j.1007-1334.2019.08.020
  中图分类号：
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吕小利, 邹红, 黎蕾, 等. 加味桃红四物汤灌胃治疗视网膜静脉阻塞大鼠的实验研究[J]. 上海中医药杂志, 2019,53(8):81-88.

LV Xiaoli, ZOU Hong, LI Lei, et al. Experimental study on Supplemented Taohong Siwu Decoction for gavage administration in treatment of retinal vein occlusion in rats [J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(8):81-88.
吕小利, 邹红, 黎蕾, 等. 加味桃红四物汤灌胃治疗视网膜静脉阻塞大鼠的实验研究[J]. 上海中医药杂志, 2019,53(8):81-88. DOI： 10.16305/j.1007-1334.2019.08.020.

LV Xiaoli, ZOU Hong, LI Lei, et al. Experimental study on Supplemented Taohong Siwu Decoction for gavage administration in treatment of retinal vein occlusion in rats [J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(8):81-88. DOI： 10.16305/j.1007-1334.2019.08.020.

摘要

目的：通过孟加拉玫瑰红联合激光光动力建立SD大鼠视网膜静脉阻塞(RVO)模型,并给予加味桃红四物汤(THSW)灌胃,观察评价THSW对大鼠RVO眼底病变的影响。方法：①用孟加拉玫瑰红激光光动力的方法建立SD大鼠RVO模型。②采用高、中、低浓度的THSW灌胃模型3周,定期观察模型眼底。结果：FFA以及光、电镜观察,孟加拉玫瑰红联合激光光动力成功建立SD大鼠RVO模型。大鼠模型THSW灌胃眼底观察发现:THSW对于模型大鼠眼底病变的改善优于模型的自然病程,其中以高浓度中药组最明显。结论：加味桃红四物汤灌胃RVO模型大鼠可以减轻视网膜出血、水肿等眼底病变。

Abstract

Objective:To observe and evaluate the effect of Supplemented Taohong Siwu Decoction (THSW) on retinal vein occlusion (RVO) in rats by establishing the model of RVO in SD rats by using Rose Bengale combined with laser photodynamics and THSW was given by gavage. Methods① The model of RVO in SD rats was established by using Rose Bengale combined with laser photodynamics. ②THSW at high, medium and low concentrations was given by gavage for 3 weeks and the fundus was observed at regular intervals. Results:The model of RVO in SD rats was successfully established, as shown by FFA and the light and electron microscopy. In the fundus, it was found out that the improvement of fundus lesions with THSW was superior to the natural course of the model, with most significant effect in the high concentration group. Conclusion:Supplemented Taohong Siwu Decoction given by gavage reduces fundus lesions including retinal hemorrhage and edema in rat model of RVO.

关键词

视网膜静脉阻塞加味桃红四物汤大鼠

Keywords

retinal vein occlusionSupplemented Taohong Siwu Decoctionrats

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