香青兰总黄酮对低氧环境所致大鼠肺损伤的保护作用

祖丽皮耶·艾乃斯; 杨涛; 是文辉; 宋来阳; 董翔; 刘江伟; 许永华; 迪丽努尔·买买提依明

doi:10.16305/j.1007-1334.2019.05.021

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香青兰总黄酮对低氧环境所致大鼠肺损伤的保护作用

实验研究 | 更新时间：2022-08-31

- 香青兰总黄酮对低氧环境所致大鼠肺损伤的保护作用
- Protective effect of total flavones of Dracocephalum Moldavica L. on lung injury induced by hypoxic environment in rats
- 上海中医药杂志 2019年53卷第5期页码：88-92
- 作者机构：
  
  1. 新疆医科大学,新疆,乌鲁木齐,830000
  2. 新疆医科大学中心实验室,新疆,乌鲁木齐,830011
  3. 中国人民解放军新疆军区总医院新疆特殊环境医学重点实验室,新疆,乌鲁木齐,830000
  4. 新疆医科大学第一附属医院综合心脏内科,新疆乌鲁木齐,830054
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81660695);新疆维吾尔自治区中医民族医与西医结合研究项目(2016-04-04)
- DOI：10.16305/j.1007-1334.2019.05.021
  中图分类号：
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祖丽皮耶·艾乃斯, 杨涛, 是文辉, 等. 香青兰总黄酮对低氧环境所致大鼠肺损伤的保护作用[J]. 上海中医药杂志, 2019,53(5):88-92.

ZULIPIYE Ainaisi, YANG Tao, SHI Wenhui, et al. Protective effect of total flavones of Dracocephalum Moldavica L. on lung injury induced by hypoxic environment in rats[J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(5):88-92.
祖丽皮耶·艾乃斯, 杨涛, 是文辉, 等. 香青兰总黄酮对低氧环境所致大鼠肺损伤的保护作用[J]. 上海中医药杂志, 2019,53(5):88-92. DOI： 10.16305/j.1007-1334.2019.05.021.

ZULIPIYE Ainaisi, YANG Tao, SHI Wenhui, et al. Protective effect of total flavones of Dracocephalum Moldavica L. on lung injury induced by hypoxic environment in rats[J]. Shanghai Journal of Traditional Chinese Medicine, 2019,53(5):88-92. DOI： 10.16305/j.1007-1334.2019.05.021.

摘要

目的：探讨香青兰总黄酮对低氧环境所致大鼠肺损伤的保护作用。方法：将60只SD大鼠随机分为正常组(CG)、高原组(MG)、阳性组(NE)、香青兰总黄酮高剂量组(DML.H)、香青兰总黄酮中剂量组(DML.M)、香青兰总黄酮低剂量组(DML.L)。除正常组(10只)外,其余50只大鼠建立慢性高原病模型。各组进行相应干预。测定各组大鼠肺动脉压力,血清中EPO、VEGF及肺组织SOD、MDA和GSH-Px活性,观察大鼠肺组织病理学改变。结果：与正常组比较,慢性高原病大鼠肺动脉压力升高,血清EPO、VEGF含量上升,肺组织中SOD、GSH-Px含量降低,MDA含量升高(P<0.05)。与高原组比较,香青兰总黄酮各剂量组大鼠肺动脉压力不同程度下降(P<0.05),血清中EPO、VEGF含量降低(P<0.05),肺组织SOD、GSH-Px含量升高(P<0.05),MDA含量降低(P<0.05)。结论：香青兰总黄酮可改善由缺氧引起的肺动脉高压,减少氧化应激,增强抗氧化机制,对低氧环境所致肺损伤具有一定的保护作用。

Abstract

Objective:To explore the protective effect of total flavonoids of Dracocephalum Moldavica L. on hypoxia-induced lung injury in rats. Methods60 SD rats were randomly assigned into the following groups:control group, model group, nifedipine-treated group (NE), and high-dose group (DML.H), medium-dose group (DML.M) and low-dose group (DML.L) of total flavonoids of Dracocephalum Moldavica L. Excluding the control group (10 rats), the model of chronic mountain sickness was established with the other 50 rats. Each group of rats received corresponding intervention. Pulmonary artery pressure, the content of EPO and VEGF in serum, and the content of SOD, MDA and GSH-Px in lung tissues were determined and the pathological changes in lung tissues of rats were observed in each group. Results:Compared with the control group, the pulmonary artery pressure increased, the content of EPO and VEGF in serum increased, the content SOD and GSH-Px in lung tissues decreased, and the content of MDA increased in rats with chronic mountain sickness (P<0.05). Compared with the model group, the pulmonary artery pressure decreased to varying degrees (P<0.05), the content of EPO and VEGF in serum decreased (P<0.05), the content of SOD and GSH-Px in lung tissues increased (P<0.05), and the content of MDA decreased (P<0.05) in the DML.H, DML.M and DML.L groups. Conclusion:The total flavonoids of Dracocephalum Moldavica L. improves pulmonary arterial hypertension caused by hypoxia, reduces oxidative stress and enhances the antioxidant mechanism. It has certain protective effect on lung injury caused by hypoxic environment.

关键词

香青兰低氧环境肺损伤大鼠

Keywords

Dracocephalum Moldavuca Lhypoxic environmentlung injuryrats

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