Objective:To observe the clinical efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in improving cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer (NSCLC). Methods80 NSCLC patients with cancer-related fatigue were randomly assigned into treatment group and control group, 40 patients in each group. Both groups were given chemotherapy, and during chemotherapy the control group was administered Sijunzi decoction or Shashen Maidong decoction, and the treatment group was treated with Kangliu Jiandu recipe combined with Shenqi Fuzheng injection. The course of treatment was 16 weeks. Changes in the scores on Piper fatigue scale, the Quality of Life Questionnaire-Cancer (QLQ-C30) scores, blood routine, natural killer (NK) cells, T lymphocyte subsets (CD3,+, CD4,+, CD8,+, CD4,+, /CD8,+,), interleukin-6 (IL-6) levels were compared between the two groups.  Results:①=1\*GB3There were 2 and 3 drop-outs in the treatment group and the control group respectively. 75 patients completed the trial, including 38 and 37 patients in the treatment group and the control group respectively. ②After treatment, there was better improvement of fatigue symptoms in the treatment group than in the control group (P,<,0.05), and the quality of life was higher in the treatment group than in the control group (P,<,0.05). ③=3\*GB3After treatment, the levels of hemoglobin, white blood cells and absolute neutrophils were reduced in both groups compared to those before treatment (P,<,0.05); and the levels were higher in the treatment group than in the control group (P,<,0.05). ④There were no significant differences in the levels of immune indexes (NK, CD3,+, CD4,+, CD8,+, CD4,+,/CD8,+, IL-6) in the treatment group before and after treatment (P,>,0.05), while the levels showed significant differences in the control group before and after treatment (P,<,0.05). The levels of NK, CD4,+, IL-6 and CD4,+,/CD8,+, were higher in the treatment group than in the control group after treatment (P,<,0.05).  Conclusion:Kangliu Jiandu recipe combined with Shenqi Fuzheng injection can significantly improve the fatigue symptoms and quality of life in patients with intermediate-terminal non-small cell lung cancer, and the mechanism of action may be related to relieving bone marrow depression and regulating immune function.