Objective:To observe the effect of acupuncture combined with Western medicine on serum T lymphocyte subsets, inflammatory factors and vascular cell adhesion molecule-1 (VACM-1) in patients with moderate to severe intermittent allergic rhinitis. Methods120 patients with moderate to severe intermittent allergic rhinitis were randomly assigned into control group and treatment group, 60 patients in each group. The control group was treated with fluticasone propionate nasal spray and azostatin hydrochloride tablets, and the treatment group was given acupuncture on top of treatment in the control group. Treatment duration was 28 days. Clinical efficacy was observed and changes in TCM syndrome score, serum T lymphocyte subsets, inflammatory factors [interleukin-4 (IL-4) and interleukin-10 (IL-10)] and VACM-1 levels were compared.  Results:①The total effective rate was 95.0% and 81.7% in the treatment and control groups, respectively. The clinical efficacy in the treatment group was superior to that in the control group (P,<,0.05). ②At 7 days after treatment, the TCM syndromes in both groups (stuffy nose, intolerably itchy nose, runny nose and frequent sneezing) were improved compared to those before treatment. There was better improvement in the treatment group than in the control group at 7 days after treatment (P,<,0.05). ③At 7 days after treatment, in both groups, the levels of serum CD3,+, CD4,+, CD4,+,/CD8,+, increased compared to those before treatment (P,<,0.05), while the levels of serum CD8,+, IL-4, IL-10 and VCAM-1 were lower than those before treatment (P,<,0.05). There were significant differences in the above indicators between the groups at 7 days after treatment (P,<,0.05).  Conclusion:Acupuncture combined with Western medicine shows satisfactory effect in the treatment of moderate to severe intermittent allergic rhinitis. It can effectively alleviate the clinical symptoms of patients, improve the immune status of the body and reduce inflammatory reactions.