Objective:To explore the clinical efficacy of Qiangxin Jieyu Decoction combined with conventional therapy in the treatment of chronic heart failure complicated with depression in the elderly. MethodsSixty elderly patients with chronic heart failure complicated with depression were randomly assigned into treatment group and control group, 30 patients in each group. Patients in both groups were given the routine treatment for heart failure. On top of this, patients in the control group were treated with sertraline, and those in the treatment group were given Qiangxin Jieyu Decoction. The treatment duration was 8 weeks in both groups. The treatment effect on depression was evaluated. Lee`s heart failure score, total score on Hamilton Depression Scale (HAMD), plasma NT-proBNP level and left ventricular ejection fraction (LVEF) were observed.  Results:①=1\*GB3The total effective rate in depression treatment was 93.3% and 83.3% in the treatment and control groups, respectively; and there was statistically significant difference in the treatment effect on depression between the groups (P<0.05). ②=2\*GB3After treatment, the total HAMD-24 score and Lee`s heart failure score decreased (P<0.05), the LVEF level increased (P<0.05), and the NT-proBNP level decreased (P<0.05) significantly in both groups; and there were statistically significant differences in these indicators between the groups (P<0.05).  Conclusion:Qiangxin Jieyu Decoction is effective in the treatment of chronic heart failure complicated with depression in the elderly. It can effectively control the patients’ depressive symptoms and improve heart function.