Objective:To observe the clinical efficacy of acupuncture and moxibustion in the treatment of constipation in patients with middle- and advanced-stage Parkinson’s disease (PD) and the effect on medication compliance. Methods72 middle- and advanced-stage PD patients with constipation were randomly assigned into treatment group and control group, 36 patients in each group. Routine treatment for PD was given to patients in both groups, and in addition, patients in the control group took Maren Soft Capsules and those in the treatment group were treated with acupuncture and moxibustion. The treatment course was 28 days in both groups. The clinical efficacy was observed and changes in the score on unified Parkinson’s disease rating scale (UPDRS) II and III, constipation score and medication compliance were compared.  Results:①The overall effective rate was 72.2% and 44.4% in the treatment and control groups respectively, and the clinical efficacy in the treatment group was superior to that in the control group (P<0.05). ②Constipation improved significantly in both groups after treatment compared to that before treatment (P<0.05); and it showed significantly greater improvement in the treatment group than in the control group after treatment (P<0.05). ③The UPDRS II score decreased in both groups after treatment compared to that before treatment (P<0.05), and it was lower in the treatment group than in the control group after treatment (P<0.05). ④Medication compliance improved significantly in both groups after treatment compared to that before treatment (P<0.05), and it was significantly better in the treatment group than in the control group after treatment (P<0.05).  Conclusion:Acupuncture and moxibustion show satisfactory efficacy in the treatmentof constipation in patients with middle- and advanced-stage Parkinson’s disease. They can effectively relieve constipation and improve the patients’ daily activities and medication compliance.