This paper discusses the application of the method for promoting blood circulation and removing blood stasis in the differentiation and treatment of malignant tumors. The pathological changes of malignant tumor are closely related to the state of blood stasis and the products originated from blood stasis. The method should be used when it is appropriate to the pathogenesis, to the course of disease, to the site of disease and to the pathological products. Physicians should focus on the cause of blood stasis, know the forming time, recognize the site and understand the degree of blood stasis in treating the disease. The prescription of promoting blood circulation should be used to strengthen healthy qi first for treating the root of the disease and be stopped using when it works. Meanwhile, the method of nourishing blood is often used to prevent blood stasis from occurring again.