This paper introduces the unique clinical thinking and experience of Professor Yan Shiyun in the treatment of cardiac disease. In the treatment of the disease, he emphasizes the exuberant and debilitating changes between body healthy qi and pathogenic factors, focuses on qi, blood and the relations among five Zang-organs. The characteristic methods of treating the diseases are mainly regulating yin-yang, especially emotion. The decoctions he prescribed often include pills of Chinese medicines with medicinal paste for consolidating vital root. Professor Yan is flexible in prescribing Chinese medicines and good at using insect drugs, compound prescriptions as well as couplet and group medicines. One proven case is presented.