Objective:To observe the preventive and therapeutic effects of Modified Jinsu Pill on pediatric febrile convulsion (FC). Methods250 children patients with febrile convulsion were randomly divided into the treatment group (180 cases) and control group (70 cases). The control group was treated with routine western medicine in acute stage and no intervention in remission stage, the treatment group was treated with Modified Jinsu Pill two weeks after the therapy of routine western medicine in acute stage, with a treatment course of 2.5 months and follow-up of 1 year. The comprehensive efficacy was observed. The recurrence rate of febrile convulsion, the lowest temperature inducing FC and the abnormity rate of encephalogram (ECG) were compared.  Results:①Finally 228 cases completed the trial, among 165 cases in the treatment group and 63 cases in the control group. ②The effective rates were 69.7% in the treatment group and 54.0% in the control group. The comprehensive efficacy of the treatment group was better than that of the control group, with statistically significant difference (P<0.05). ③The recurrence rate of convulsion in the treatment group was obviously lower than that in the control group, with statistically significant difference (P<0.05). ④Among the patients with recurrence convulsion, compared between treatment before and follow-up, there was statistically significant difference on the lowest temperature inducing FC in both groups, and the temperature was obviously increased in both groups (P<0.05). However, during the follow-up, there was no statistically significant difference on the lowest temperature inducing FC between the two groups (P>0.05). ⑤After follow-up for one year, the abnormity rates of ECG were 9.5% in the treatment group and 21.3% in the control group, the abnormity rate of ECG of the treatment group was obviously lower than that of the control group, with statistically significant difference (P<0.05).  Conclusion:Modified Jinsu Pill exerts certain preventive effects on the recurrence of pediatric febrile convulsion, as well as the brain damage induced by febrile convulsion.