Objective:To optimize the extraction process parameters of Compound Baizhi Zhitong Capsule on the basis of orthogonal test combined with fingerprint and information entropy as comprehensive evaluation. MethodsOrthogonal test was conducted to determine the extraction ratio, extract yield and fingerprint similarity of chlorogenic acid, ferulic acid, imperatorin, isoimperatorin as comprehensive evaluation indexes. Information entropy method was used to determine the objective weight of each index to achieve the orthogonal test optimization on extraction process.  Results:The optimum extraction process were as follows: extraction with 70% alcohol at 10 times amount of the drug weight for three times, each time for one hour.  Conclusion:The optimization of extraction process on the basis of orthogonal test combined fingerprint and information entropy can be used for optimizing the extraction process of Compound Chinese medicine, with high specificity and sensitirity.