醒脾化痰法为主中药对脾虚痰盛型原发性癫痫影响的临床试验

李巧彤; 程光宇; 张奇; 程为平

doi:10.16305/j.1007-1334.2018.11.012

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醒脾化痰法为主中药对脾虚痰盛型原发性癫痫影响的临床试验

临床试验 | 更新时间：2022-08-31

- 醒脾化痰法为主中药对脾虚痰盛型原发性癫痫影响的临床试验
- Clinical study on effects of Chinese medicine of activating spleen and dissipating phlegm on primary epilepsy with syndrome of spleen deficiency and abundant phlegm
- 上海中医药杂志 2018年52卷第11期页码：42-45
- 作者机构：
  
  1. 黑龙江中医药大学研究生院,黑龙江,哈尔滨,150040
  2. 黑龙江中医药大学附属第一医院癫痫诊疗中心,黑龙江,哈尔滨,150040
  3. 黑龙江省中医医院肾九科,黑龙江,哈尔滨,150036
  4. 黑龙江中医药大学附属第一医院针灸二科,黑龙江,哈尔滨,150040
- 作者简介：
- 基金信息：
  
  黑龙江省自然科学基金面上项目(H201470)
- DOI：10.16305/j.1007-1334.2018.11.012
  中图分类号：
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李巧彤, 程光宇, 张奇, 等. 醒脾化痰法为主中药对脾虚痰盛型原发性癫痫影响的临床试验[J]. 上海中医药杂志, 2018,52(11):42-45.

LI Qiaotong, CHENG Guangyu, ZHANG Qi, et al. Clinical study on effects of Chinese medicine of activating spleen and dissipating phlegm on primary epilepsy with syndrome of spleen deficiency and abundant phlegm[J]. Shanghai Journal of Traditional Chinese Medicine, 2018,52(11):42-45.
李巧彤, 程光宇, 张奇, 等. 醒脾化痰法为主中药对脾虚痰盛型原发性癫痫影响的临床试验[J]. 上海中医药杂志, 2018,52(11):42-45. DOI： 10.16305/j.1007-1334.2018.11.012.

LI Qiaotong, CHENG Guangyu, ZHANG Qi, et al. Clinical study on effects of Chinese medicine of activating spleen and dissipating phlegm on primary epilepsy with syndrome of spleen deficiency and abundant phlegm[J]. Shanghai Journal of Traditional Chinese Medicine, 2018,52(11):42-45. DOI： 10.16305/j.1007-1334.2018.11.012.

摘要

目的：观察醒脾化痰法为主中药联合西药治疗脾虚痰盛型原发性癫痫的临床疗效。方法：将60例脾虚痰盛型原发性癫痫患者随机分为治疗组与对照组,每组30例。对照组予卡马西平治疗,治疗组在对照组治疗措施基础上加服醒脾化痰法为主中药治疗。两组总疗程均为1年,疗程期间每3个月随访1次,观察临床疗效,比较癫痫发作频率、持续时间及脑电图异常率的变化情况。结果：①治疗组、对照组总有效率分别为83.3%、70.0%；组间临床疗效比较,治疗组明显优于对照组(P<0.05)。②治疗期间各观察时点与治疗前组内比较,两组癫痫发作频率及持续时间差异均有统计学意义(P<0.05)；组间治疗期间各观察时点比较,治疗组癫痫发作频率明显少于对照组,持续时间明显短于对照组(P<0.05)。③两组治疗期间各观察时点比较,脑电图异常率差异有统计学意义,治疗组均明显低于对照组(P<0.05)。结论：醒脾化痰法为主中药联合西药治疗脾虚痰盛型原发性癫痫,疗效优于单用西药,能够更明显减少癫痫的发作频率,缩短癫痫持续时间,并能改善脑电图异常。

Abstract

Objective:To observe the clinical efficacy of Chinese medicine of activating spleen and dissipating phlegm combined with western medicine on primary epilepsy with syndrome of spleen defficiency and abundant phlegm. Methods60 patients of primary epilepsy with syndrome of spleen deficiency and abundant phlegm were randomly divided into the treatment group and control group, 30 cases in each group. The control group was treated with carbamazepine, the treatment group was treated with Chinese medicine of activating spleen and dissipating phlegm based on the treatment for the control group, with a total course of one year. During the treatment, the patients were followed-up every 3 months. The clinical efficacy was observed, the changes of attack frequency, duration and abnormal rate of electroencephalogram (EEG) were compared. Results:①The total effective rates were 83.3% in the treatment group and 70.0% in the control group, the clinical efficacy of the treatment group was obviously better than that of the control group (P<0.05). ②In both groups, there were statistically significant differences on the frequency and duration of epileptic seizures between treatment before and different observation time points during treatment (P<0.05). At different observation time points during treatment, the frequency of epileptic seizure in the treatment group was significantly fewer than that in the control group, and the duration of epileptic seizure in the treatment group was significantly shorter than that in the control group (P<0.05). ③At different observation time points during the treatment, there was statistically significant difference on the abnormal rate of EEG between the two groups, and the abnormal rate in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion:The efficacy of Chinese medicine of activating spleen and dissipating phlegm combined with western medicine in treating primary epilepsy with syndrome of spleen deficiency and abundant phlegm is superior to western medicine alone, which can more significantly reduce the frequency of epileptic seizures, shorten the duration of epileptic seizures and improve EEG abnormalities.

关键词

癫痫醒脾化痰法脾虚痰盛证石甘散

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