Premenopausal syndrome due to depression syndrome is premenopausal syndrome induced by internal injury caused by excess of seven emotions. Its clinical manifestations include physical symptoms and mental symptoms. Physical symptoms can be divided into menstrual disorders and non-menstrual disorders. Stagnation of liver qi,hyperactivity of heart-liver fire,deficiency of qi and blood,phlegm stasis,stirring wind due to yin deficiency,stagnation of liver qi and spleen deficiency and so on,all of which is the common pathogenesis of premenopausal syndrome due to depression syndrome. Contemporary Chinese medicine has gradually realized the existence of premenopausal syndrome due to depression syndrome. The treatment is no longer confined to tonifying kidney,but began to use more and more therapies based on relieving depression,such as dispersing stagnated liver qi for relieving qi stagnation,nourishing blood for tranquillization. Modern studies have shown that psychosocial factors can affect the onset of perimenopausal syndrome,and anti-depression,hormone replacement and psychological cognitive therapy can help to relieve the clinical symptoms,which is the strong evidence for premenopausal syndrome due to depression.