Objective:To investigate the clinical efficacy of Tiaopi Shugan Yishen Decoction combined with chemotherapy in the treatment of postoperative recurrence of triple-negative breast cancer. Methods50 patients with postoperative recurrence of triple-negative breast cancer were randomly divided into the treatment group and control group,25 cases in each group. The control group was treated with the XEC chemotherapy program (cyclophosphamide + epirubicin + capecitabine),and the treatment group was treated with Tiaopi Shugan Yishen Decoction based on the treatment for the control group,with a course of 6 months. The clinical efficacy on tumor and adverse reactions after chemotherapy were observed. The changes on life quality scores and levels of peripheral blood T lymphocyte subsets were compared.  Results:①The total effective rates were 84.0% in the treatment group and 64.0% in the control group. The efficacy on tumor in the treatment group was obviously better than that in the control group (P,<,0.05). ②After treatment,the life quality scores of all items in the treatment group were obviously higher than those in the control group (P,<,0.05). ③After treatment,the levels of CD3,+,CD4,+, and CD4,+,/CD8,+, in the treatment group were obviously higher than those in the control group,while the CD8,+, level was obviously lower than that in the control group (P,<,0.05). ④The myelosuppression degree in the treatment group was obviously slighter than that in the control group (P,<,0.05),and the gastrointestinal toxic and side effects in the treatment group was also obviously slighter than that in the control group (P,<,0.05).  Conclusion:Tiaopi Shugan Yishen Decoction combined with chemotherapy shows satisfactory efficacy in the treatment of triple-negative breast cancer,which can improve the life quality of patients,ameliorate the immune function (peripheral blood lymphocyte subsets) and reduce the myelosuppression and gastrointestinal toxic and side effects caused by chemotherapy alone.