Objective:To investigate the correlation between blood stasis syndrome and severity of coronary artery lesions and endothelial function in patients with coronary atherosclerosis. Methods79 patients who performed the first coronary angiography and diagnosed as coronary atherosclerosis were recruited. Gensini score was calculated according to the results of angiography,and the brachial artery endothelium-dependent vasodilation function was detected by flow-mediated dilatation (FMD). The scores of traditional Chinese medicine (TCM) syndrome and blood stasis syndrome were recorded. The distribution of TCM syndrome elements and the correlation between blood stasis syndrome and FMD and Gensini score were analyzed.  Results:Among the TCM syndrome elements of patients with coronary atherosclerosis,blood stasis syndrome was the most common syndrome. The FMD value of patients with blood stasis syndrome was lower than that of patients without blood stasis syndrome,and the Gensini score was higher than that of patients without blood stasis syndrome (P<0.05,P<0.01). The blood stasis syndrome score was negatively correlated with FMD value (r=-0.597,P<0.01),and positively correlated with Gensini score (r=0.693,P<0.01). The blood stasis syndrome score was positively correlated with fasting blood glucose (r=0.358,P<0.01),and positively correlated with glycosylated hemoglobin (r=0.264,P<0.05). The FMD value was negatively correlated with Gensini score (r=-0.700,P<0.01).  Conclusion:The more obvious the blood stasis syndrome is in patients with coronary atherosclerosis,the more serious the degree of coronary artery lesion and the damage of endothelial function are.