This paper reviews the research progress of intervention of Chinese medicine on protein and gene expressions of uric acid transporters. The uric acid transporters play an important role in the transport of uric acid. Researches have showed that some single herbs, effective components in single herbs and compound recipes can decrease the blood uric acid level in hyperuricemia animal model through interfering the expressions of uric acid transporters. Molecular biology technology and gene technology can be used to elucidate the targets and mechanisms of Chinese medicine in lowering uric acid.