Objective:To observe the clinical efficacy of Qiyeling Decocotion combined with routine western medicine therapy in treating radiation pneumonitis. Methods80 patients with radiation pneumonitis were randomly divided into the control group and observation group, 40 cases in each group. The control group was treated with routine western medicine therapy and the observation group was orally treated with Qiyeling Decocotion based on the treatment for the control group, with a course of 2 months. The clinical efficacy was observed, the traditional Chinese medicine (TCM) syndrome scores, FACT-G scores, serum inflammatory factors including transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and pulmonary function indexes were compared.  Results:①The total effective rates were 80.0% in the observation group and 67.5% in the control group, the clinical efficacy of the observation group was better than that of the control group (P,<,0.05). ②Compared with treatment before, the scores of cough, expectoration, soreness of waist and weakness of legs, dizziness and tinnitus were decreased in the observation group after treatment (P,<,0.05), the scores of cough and expectoration were decreased in the control group after treatment (P,<,0.05).After treatment, the improvement on TCM syndrome in the observation group was better than that in the control group (P,<,0.05). ③Compared with treatment before, the FEV,1,/FVC% and FEV,1,% were increased in both groups after treatment (P,<,0.05), the FVC in the observation group was also increased after treatment (P,<,0.05). After treatment, the FVC, FEV,1,/FVC% and FEV,1,% in the observation group were higher than those in the control group (P,<,0.05). ④After treatment, the physiological status score, function status score and the total score of FACT-G scale were increased in the observation group compared with treatment before (P,<,0.05). The physiological status score, social or family status score, function status score and the total score of scale in the observation group were higher than those in the control group (P,<,0.05). ⑤After treatment, the serum levels of TGF-β1, TNF-α and IL-6 were decreased in the observation group compared with treatment before (P,<,0.05). After treatment, the serum levels of TGF-β1, TNF-α and IL-6 in the observation group were lower than those in the control group (P,<,0.05).  Conclusion:Qiyeling Decoction combined with routine western medicine therapy shows satisfactory efficacy in treating radiation pneumonitis, which can obviously ameliorate the clinical symptoms and pulmonary function of patients, control the inflammatory response and improve the quality of life.