This article discusses the etiology, pathology, syndrome and treatment of dysmenorrhea due to depression syndrome. Internal injury caused by excess seven emtions can cause qi and blood failing to transport and menstrual blood stasis of meridians, all of these lead to dysmenorrhea. Stagnation of liver qi and liver fire is the cause of dysmenorrhea due to depression syndrome. All pain originate from heart and the five minds affect heart, the dysfunction of heart governing blood and vessels can cause disorders of blood and qi and induce dysmenorrhea. The clinical manifestations of dysmenorrhea are often accompanied by emotional disorders and/or a series of physical symptoms. The treatment principle for dysmenorrhea due to depression syndrome is symptomatic treatment in acute condition to relieve pain and radical treatment in chronic case to relieve depression. Stagnation and deficiency may cause the pain, and the pain could be alleviated after dredging and nourishing. When there is stagnation, the pain could be felt; and when the stagnation is resolved, the pain could be eliminated. In the treatment of dysmenorrhea due to depression syndrome, prevention is more important than treatment.