Objective:To observe the efficacy of Jianpi Moji Jiedu Decoction combined with routine western medicine in the treatment of hepatitis C cirrhosis in compensatory stage. Methods66 patients with hepatitis C cirrhosis in compensatory stage were randomly divided into the control group and treatment group,33 cases in each group. The control group was treated with routine western medicine,and the treatment group was treated with Jianpi Moji Jiedu Decoction based on the treatment for the control group,with a course of 48 weeks. The changes on liver function indexes,Child-Pugh score,virological response,serum liver fibrosis indexes,liver stiffness measurement value and score of liver B-mode ultrasound were compared.  Results:①The response rate in the early stage and at the end of the treatment and the sustained response rate in the treatment group were higher than those in the control group,with statistically significant differences(P<0.05). ②Compared with treatment before,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL) and Child-Pugh score were decreased(P<0.05) while the albumin(ALB) level was increased(P<0.05) in the treatment group after treatment. Only the ALT and AST levels were decreased in the control group after treatment(P<0.05). After treatment,there were statistically significant differences on the liver function indexes and Child-Pugh score between the two groups(P<0.05). ③Compared with treatment before,the levels of hyaluronic acid(HA),laminin(LN),procollagen type III(PCIII) and collagen type IV(Ⅳ-C),the liver stiffness measurement value,the liver score and the B-mode ultrasound score were decreased in both groups after treatment(P<0.05). After treatment,there were statistically significant differences on serum liver fibrosis indexes,liver stiffness measurement value,liver score and B-mode ultrasound score between the two groups(P<0.05).  Conclusion:Jianpi Moji Jiedu Decoction combined with routine western medicine in the treatment of hepatitis C cirrhosis in compensatory stage can effectively improve the antiviral efficacy,ameliorate the liver function of patients and inhibit the hepatic fibrosis process.