Internal injury caused by excess of seven emotions can lead to seminal deficiency and male infertility. Such as jealousy and narrow-mind,or sorrow and worry,or thoughtful and overtaxed mind-spirit,or irritability and indulgence,or stagnation of liver qi,or even the discord of couples feelings,all the ones can lead to infertility. These can be named as infertility due to depression syndrome. The main pathogenesis is disharmony between heart and kidney that impair spirit,liver stagnation transforming into fire that impair yin,spleen failing to govern transportation due to spleen deficiency that impair qi. If one want to have children,health-preservation is the most important. It could cleanse one’s heart and limit one’s desires,clam the psychological state,and not excessively think and consume mind-spirit；it should avoid excessive happy and anger,pay attention to temperance and essence nourishment,and make sure to enjoy ease of mind. The second is the combination of health-preservation and seed drugs therapy. The key of seed drug treatment is restoring normal coordination between heart and kidney,but not only tonifying kidney. The drugs of nourishing heart for tranquillization and relieving depression can be used,or even it is only emphasized the treatment principle of nourishing heart for tranquilizing and sedating mind,dispersing stagnated liver qi for relieving qi stagnation. The antidepressant western medicine shows the adverse effects on sexual function,so the therapy of traditional Chinese medicine presents certain advantages in the treatment of infertility due to depression syndrome.