Objective:To observe the effects of traditional Chinese medicine (TCM) clinical pathway on life quality of postoperative patients of colorectal cancer with spleen deficiency. Methods60 postoperative patients of colorectal cancer with spleen deficiency were randomly divided into the pathway group and non-pathway group, 30 cases in each group. The patients in the non-pathway group were treated according to the symptoms, and the patients in the pathway group were treated according to the established TCM clinical pathway, with a course of 12 weeks. The changes on TCM syndrome score and EORTCQLQ-C30 scale score were compared.  Results:①Compared with treatment before, the TCM syndrome score was decreased in the pathway group after treatment (P<0.01), but no obvious change was observed in the non-pathway group (P>0.05). After treatment, there was statistically significant difference on the TCM syndrome score between the two groups (P<0.01). ②Compared with treatment before, the scores of physical and cognitive function in function subscale were increased in the pathway group after treatment (P<0.01), and no obvious changes on all the scores were observed in the non-pathway group (P>0.05). After treatment, there were statistically significant differences on the physical and cognitive function scores between the two groups (P<0.01). ③Compared with treatment before, the scores of fatigue, nausea and vomiting, dyspnea and diarrhea in symptom subscale were decreased in the pathway group after treatment (P<0.05), while only the symptom score of dyspnea was decreased in the non-pathway group (P<0.05). After treatment, the improvements on fatigue, nausea and vomiting, diarrhea and appetite in the pathway group were better than those in the non-pathway group (P<0.01). ④Compared with treatment before, the score of general health subscale was increased in the pathway group (P<0.01) and decreased in the non-pathway group (P<0.01) after treatment. After treatment, there was statistically significant difference on the score of general health subscale between the two groups (P<0.01).  Conclusion:The TCM clinical pathway can improve the clinical symptoms and enhance the life quality of postoperative patients of colorectal cancer with spleen deficiency.