Objective:To study the clinical efficacy of Feiyanning Granule in the treatment of advanced lung adenocarcinoma with syndrome of deficiency of both essence and qi. MethodsA prospective randomized controlled study was performed. 100 patients of advanced lung adenocarcinoma with syndrome of deficiency of both essence and qi were randomly divided into the treatment group (49 cases) and the control group (51 cases). The patients in the treatment group were treated with Feiyanning Granule and the patients in the control group were treated with analogue of Feiyanning Granule,with a course of 2 months. The short-term efficacy and the medication safety were observed. The changes on the TCM syndromes,Karnofsky performance status (KPS) score,body weight and serum tumor markers were compared.  Results:①Finally 44 cases in the treatment group and 43 cases in the control group completed the trial. ②The disease control rates were 79.5% in the treatment group and 53.5% in the control group. The disease control rate in the treatment group was significantly higher than that in the control group (P<0.05). ③The improvement rates of TCM syndromes were 81.8% in the treatment group and 23.3% in the control group. The improvement rate of TCM syndromes in the treatment group was significantly higher than that in the control group (P<0.05). ④The total effective rates of KPS score were 93.2% in the treatment group and 65.1% in the control group. The total effective rate of KPS score in the treatment group was significantly higher than that in the control group (P<0.05). The total effective rate of body weight were 79.5% in the treatment group and 69.8% in the control group. There was no statistically significant difference on the total effective rates of body weight between the two groups (P>0.05). ⑤After treatment,there were statistically significant differences on the levels of CA125 and CA50 between the two groups (P<0.05),and the levels in the treatment group were significantly lower than those in the control group (P<0.05). ⑥There was no statistically significant difference on the incidence rate of adverse reactions between the two groups (P>0.05).  Conclusion:Feiyanning Granule shows satisfactory clinical efficacy in the treatment of advanced lung adenocarcinoma with syndrome of deficiency of both essence and qi,which can obviously stabilize the illness condition,improve the clinical symptoms and enhance the quality of life.