Objective:To observe the clinical efficacy of Shenge Recipe in the treatment of senile non-alcoholic steatohepatitis with syndrome of phlegm turbidity due to spleen deficiency. Methods96 elderly patients with non-alcoholic steatohepatitis were randomly divided into the treatment group and control group,48 cases in each group. Patients in both groups were treated with the proper diet and exercise regimen to control the primary disease. Meanwhile,all patients were treated with conventional hepatoprotective and anti-inflammatory drugs. In addition,the treatment group was treated with Shenge Recipe granules and the control group was treated with placebo,with a course of 6 months. The efficacy was observed by B-mode ultrasound. The liver function indexes,blood lipid levels,blood routine examination,TCM syndrome score and non-invasive liver fibrosis model index based on 4 factors(FIB-4) were compared.  Results:①Finally 80 cases completed the trial,among 39 cases in the treatment group and 41 cases in the control group. ②In the treatment group,9 cases were cured,24 cases were effective and the effective rate was 84.6%. While in the control group,3 cases were cured,19 cases were effective and the effective rate was 53.7%. There was statistically significant difference on the efficacy of B-mode ultrasound,and the effective rate in the treatment group was obviously higher than that in the control group (P<0.05). ③After treatment,the levels of alanine transaminase (ALT) and aspartate transaminase (AST) in the treatment group were significantly lower than those in the control group (P<0.05). ④After treatment,the levels of total cholesterol (TC) and triglyceride (TG) in the treatment group were significantly lower than those in the control group (P<0.05). ⑤After treatment,the TCM syndrome score in the treatment group was significantly lower than that in the control group (P<0.05). ⑥After treatment,the FIB-4 index in the treatment group was significantly lower than that in the control group (P<0.05).  Conclusion:Shenge Recipe shows satisfactory efficacy on senile non-alcoholic steatohepatitis with syndrome of phlegm turbidity due to spleen deficiency,which can obviously improve the clinical symptoms,the degree of hepatic fatty infiltration and the disorder of lipid metabolism in patients,protect the liver function,and also significantly allievate the degree of liver fibrosis.